Defect bone reconstruction by digital triplet with data-driving CT image, mechanics modeling constitutive and 3D printing prosthesis

Zhuo Zhuang

Tsinghua University

Human periarticular bone defect is a difficult disease in orthopedics. There is challenge issue to recognize anisotropy, heterogeneity of bone tissue structure and graphics by low resolution clinic-CT image. In collaboration with clinical medicine, the data driving and mechanics modeling technique for bone defect reconstruction is proposed. Data driven micro-CT and clinical-CT images are used to obtain the characteristics of cancellous bone structure and graphics. The experimental technology and numerical method are developed for predicting the mechanics parameters of animal specimen on the multi-axial stress state. The constitutive model of heterogeneous anisotropy of bone tissue is established and the parameters are deduced by numerical simulation and specimen experiment. For designing the robust cancellous prosthesis bone, a kind of spinodal lattice is designed with random, indeterminate, aperiodic, asymmetry, irregular, large space for mechanical and biological function. The digital triplets with physical environment scanning CT image, virtual environment equivalent modulus and additive manufacturing lattice design are created to guide the clinical treatment of personalized bone defects. This work has been demonstrated in some clinical applications to the benefit of patients.

Biography:

Zhuo Zhuang is a Professor, School of Aerospace Engineering, Tsinghua University, China and Vice President of International Association for Computational Mechanics (IACM). He got Ph.D. in University College Dublin, Ireland, 1995 and was honored with Honorary Doctor Degree (EngD), Swansea University, UK, 2017. He has long engaged in computation and fracture mechanics for developing new theories, innovative models and methods for challenging problems in engineering involving multiple fields and scales, finite deformation, crystal plasticity and damage up to material and structural failure. He is a chief scientist of national fundamental research projects of China. He published more than 360 papers at International and National Journals, 2 books in English as "Extended Finite Element Method”, Elsevier, 2014, ISBN: 978-0-12-407717-1 and “Dislocation Mechanism-Based Crystal Plasticity Theory and Computation”, Elsevier, 2019, ISBN:978-0-12-814591-3, as well as more than 10 books in Chinese, with total 14,000 citations.